Comparison of three methods for treatment of congenital clubfoot.

and carcinoma of the colon, and it may not be too far-fetched to suggest a common cause. Megakaryocytes and platelets have been shown to play an important part in viral multiplication in certain forms of cancer in animals (de Harven and Friend, 1960; Gross, 1963), and more recently thrombocytosis has been reported in human cancer (Levin and Conley, 1964). My own observations are in agreement with the views of the latter worker. In these circumstances the immune-suppressant role of these drugs may well be a disadvantage, and perhaps provide an explanation for both the failure of these drugs to cure and the severity of the relapses. The beneficial action of the drugs could then be attributed to an antiviral action. Further support for this view comes from recent observations on cancer chemotherapy in animals (Groupe and Rauscher, 1965) and the therapy of Burkitt's lymphoma in man (Burkitt et al., 1965).